Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To assess the accuracy of routine blood-based laboratory tests to predict mortality and deterioration to severe or critical (from mild or moderate) COVID-19 in people with SARS-CoV-2 infection. Secondary objectives Where data are available, we will investigate whether prognostic accuracy varies according to a specific measurement or test, reference standard, timing of outcome verification, sample type, study design, and setting, including prevalence of the target condition (either by stratified analysis or meta-regression).

Diagnosis of SARS-CoV-2 infection and COVID-19: accuracy of signs and symptoms;molecular, antigen, and antibody tests;and routine laboratory markers

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To assess the diagnostic accuracy of laboratory real-time polymerase chain reaction (RT-PCR) and other laboratory molecular tests to determine if a person presenting in the community or in secondary care has SARS-CoV-2 infection. To assess the diagnostic accuracy of each rapid PCR and antigen test to determine if a person presenting in the community or in secondary care has SARS-CoV-2 infection. To assess the diagnostic accuracy of each antibody test to determine if a person presenting in the community or in secondary care has SARS-CoV-2 infection, or has previously had SARS-CoV-2 infection. To assess the diagnostic accuracy of signs and symptoms to determine if a person presenting in the community, general practice, or at the emergency department has SARS-CoV-2 infection, COVID-19 pneumonia, or severe COVID-19 pneumonia/ARDS requiring hospital admission. To assess the diagnostic accuracy of routine laboratory testing to determine if a person has COVID-19 pneumonia or SARS-CoV-2 infection. Secondary objectives Where data are available, for reviews #1 to #5, we will investigate the accuracy (either by stratified analysis or meta-regression) according to: laboratory method, days of symptoms, severity of symptoms, reference standard, sample type, study design, setting;test brand and version, days of symptoms, severity of symptoms, reference standard, sample type, study design, setting;current infection or past infection, test brand and version, days of symptoms or days since symptoms resolved, reference standard, study design, setting;days of symptoms, reference standard, study design, setting;specific measurement or biomarker, days of symptoms, severity of symptoms, reference standard, sample type, study design, setting.

Imaging tests for the diagnosis of COVID-19

Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. The primary objective is to determine the diagnostic accuracy of chest imaging (computed tomography (CT), chest X-ray and ultrasound) in the evaluation of people suspected to have COVID-19. This may also refer to specific signs, such as a particular CT finding. Secondary objectives To evaluate whether these imaging tests are sufficiently accurate to rule out COVID-19 (main measure of interest will be the negative predictive value) To evaluate the rate of positive imaging in patients with initial RT-PCR negative results who have a positive result on a follow-up RT-PCR test To determine if there is an association between number of days after symptom onset, symptom severity and the findings on chest imaging for patients with COVID-19 To determine the rate of discrepancy or agreement between CT, chest X-ray and ultrasound findings To evaluate for ‘threshold’ effects of imaging findings of COVID-19 and accuracy measures To determine the rate of alternative diagnoses identified by chest imaging.